Query   'Protein kinase domain'  matched   20 Records

Record No : 1

Instance ID10521
Regular Expression[KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF]
Motif InstanceRRNLKGLNLNL
Bait Uniprot AccessionP06784
Bait Uniprot IdentifierSTE7_YEAST
Bait Gene NameSTE7
Bait OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Sequence Position9-19
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)X-ray crystallography; Pull down; Fluorescence polarization spectroscopy
Interaction ID20521
Interacting DomainProtein kinase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16364919
CommentsSaccharomyces cerevisiae MAPK kinase Ste7 docking motif 1 (9-19) that selectively binds the yeast Mitogen-activated protein kinase FUS3

Record No : 2

Instance ID10522
Regular Expression[KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF]
Motif InstanceRNTKNLSLDI
Bait Uniprot AccessionP38590
Bait Uniprot IdentifierMSG5_YEAST
Bait Gene NameMSG5
Bait OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Sequence Position29-38
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down; Fluorescence polarization spectroscopy; X-ray crystallography
Interaction ID20522
Interacting DomainProtein kinase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16364919
CommentsSaccharomyces cerevisiae Tyrosine-protein phosphatase MSG5 has a docking motif that selectively binds the yeast Mitogen-activated protein kinase FUS3

Record No : 3

Instance ID10523
Regular Expression[KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF]
Motif InstanceRRAKGAMGL
Bait Uniprot AccessionP28562
Bait Uniprot IdentifierDUS1_HUMAN
Bait Gene NameDUSP1
Bait OrganismHomo sapiens (Human)
Sequence Position54-62
Critical ResiduesP1; P2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Y2H; Co-IP
Interaction ID20523
Interacting DomainProtein kinase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11278799, 11953434
CommentsMAPK docking motif in human Mitogen-activated protein (MAP) kinase phosphatase 1 (MKP-1/CL100/DUSP1) that mediates binding to human MAP kinase 1 (or ERK-2)

Record No : 4

Instance ID10524
Regular Expression[KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF]
Motif InstanceRRLQKGNLPV
Bait Uniprot AccessionQ16828
Bait Uniprot IdentifierDUS6_HUMAN
Bait Gene NameDUSP6
Bait OrganismHomo sapiens (Human)
Sequence Position64-73
Critical ResiduesP1; P2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Mass spectrometry study of hydrogen/deuterium exchange; X-ray crystallography
Interaction ID20524
Interacting DomainProtein kinase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10811804, 17046812, 16567630
CommentsMAPK docking motif in human Mitogen-activated protein kinase phosphatase 3 (MKP3/DUSP6) that mediates binding to human MAP kinase 1 (or ERK-2)

Record No : 5

Instance ID10525
Regular Expression[KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF]
Motif InstanceRRDAADFLL
Bait Uniprot AccessionP53355
Bait Uniprot IdentifierDAPK1_HUMAN
Bait Gene NameDAPK1
Bait OrganismHomo sapiens (Human)
Sequence Position1385-1393
Critical ResiduesP1; P2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Co-IP; Pull down(GST tag)
Interaction ID20525
Interacting DomainProtein kinase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15616583
CommentsMAPK docking motif in human Death-associated protein kinase 1 (DAPK1) that mediates binding to human MAP kinase 1 (or ERK-2)

Record No : 6

Instance ID10526
Regular Expression[KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF]
Motif InstanceKGRKPRDLEL
Bait Uniprot AccessionP19419
Bait Uniprot IdentifierELK1_HUMAN
Bait Gene NameELK1
Bait OrganismHomo sapiens (Human)
Sequence Position312-321
Critical ResiduesP8; P10
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Protein Kinase Assay
Interaction ID20526
Interacting DomainProtein kinase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9925641
CommentsMAPK docking motif in human ETS domain-containing protein Elk-1 that mediates binding to mouse MAP kinase 1 (or ERK-2)

Record No : 7

Instance ID10527
Regular Expression[KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF]
Motif InstanceRSKKPKGLEL
Bait Uniprot AccessionP28324
Bait Uniprot IdentifierELK4_HUMAN
Bait Gene NameELK4
Bait OrganismHomo sapiens (Human)
Sequence Position318-327
Critical ResiduesP8; P10
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Protein Kinase Assay
Interaction ID20527
Interacting DomainProtein kinase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9925641, 11786537
CommentsMAPK docking motif in human ETS domain-containing protein Elk-4 (or SAP-1) that mediates binding to human MAP kinase 1 (or ERK-2)

Record No : 8

Instance ID10528
Regular Expression[KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF]
Motif InstanceKILKQSMTLNL
Bait Uniprot AccessionP05412
Bait Uniprot IdentifierJUN_HUMAN
Bait Gene NameJUN
Bait OrganismHomo sapiens (Human)
Sequence Position32-42
Critical ResiduesP9; P11
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20528
Interacting DomainProtein kinase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9925641, 8945519
CommentsMAPK docking motif in human Transcription factor AP-1 (or Proto-oncogene c-Jun) that mediates binding to human Stress-activated protein kinase JNK2 (or MAP kinase 9)

Record No : 9

Instance ID10529
Regular Expression[KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF]
Motif InstanceRKPDLRVVI
Bait Uniprot AccessionQ02078
Bait Uniprot IdentifierMEF2A_HUMAN
Bait Gene NameMEF2A
Bait OrganismHomo sapiens (Human)
Sequence Position269-277
Critical ResiduesP9
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Protein Kinase Assay
Interaction ID20529
Interacting DomainProtein kinase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15132737, 10330143
CommentsMouse ERK5 is targeted to human myocyte enhancer factor 2A (MEF2A) through a MAPK docking motif

Record No : 10

Instance ID10530
Regular Expression[KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF]
Motif InstanceRRGIKKKLTL
Bait Uniprot AccessionP06784
Bait Uniprot IdentifierSTE7_YEAST
Bait Gene NameSTE7
Bait OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Sequence Position62-71
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Competition Fluorescence Polarization Binding Assay
Interaction ID20530
Interacting DomainProtein kinase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16364919
CommentsSaccharomyces cerevisiae MAPK kinase Ste7 docking motif 2 (62-71) that selectively binds the yeast Mitogen-activated protein kinase FUS3

Record No : 11

Instance ID10531
Regular Expression[KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF]
Motif InstanceKRGRVPAPLNL
Bait Uniprot AccessionQ03063
Bait Uniprot IdentifierDIG1_YEAST
Bait Gene NameDIG1
Bait OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Sequence Position97-107
Critical ResiduesP9; P11
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Peptide array
Interaction ID20531
Interacting DomainProtein kinase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)14734536
CommentsSaccharomyces cerevisiae Down-regulator of invasive growth 1 (DIG1) contains a docking motif that selectively binds the yeast Mitogen-activated protein kinase KSS1

Record No : 12

Instance ID10532
Regular Expression[KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF]
Motif InstanceKRKRVPPALNF
Bait Uniprot AccessionQ03373
Bait Uniprot IdentifierDIG2_YEAST
Bait Gene NameDIG2
Bait OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Sequence Position100-110
Critical ResiduesP9; P11
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Peptide array
Interaction ID20532
Interacting DomainProtein kinase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)14734536
CommentsSaccharomyces cerevisiae Down-regulator of invasive growth 2 (DIG2) contains a docking motif that selectively binds the yeast Mitogen-activated protein kinase KSS1

Record No : 13

Instance ID10533
Regular Expression[KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF]
Motif InstanceKGKKPKGLEI
Bait Uniprot AccessionP41971
Bait Uniprot IdentifierELK3_MOUSE
Bait Gene NameElk3
Bait OrganismMus musculus (Mouse)
Sequence Position292-301
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction
Interaction ID20533
Interacting DomainProtein kinase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9925641
CommentsMAPK docking motif in mouse ETS domain-containing protein Elk-3 (Erp/Net) that mediates binding to mouse MAP kinase 1 (or ERK-2)

Record No : 14

Instance ID10534
Regular Expression[KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF]
Motif InstanceKKPTPIQL
Bait Uniprot AccessionQ02750
Bait Uniprot IdentifierMP2K1_HUMAN
Bait Gene NameMAP2K1
Bait OrganismHomo sapiens (Human)
Sequence Position4-11
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down(GST tag)
Interaction ID20534
Interacting DomainProtein kinase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11134045
CommentsThe MAPK-docking site in MAPK/ERK kinase 1 (MEK1/MAP kinase kinase 1) mediates Mitogen-activated protein kinase 3 (MAPK3/ERK1) binding to MEK1

Record No : 15

Instance ID10535
Regular ExpressionFxFP
Motif InstanceFKFP
Bait Uniprot AccessionG5EDL0
Bait Uniprot IdentifierG5EDL0_CAEEL
Bait Gene Namelin-1
Bait OrganismCaenorhabditis elegans
Sequence Position420-423
Critical ResiduesP4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Protein kinase assay
Interaction ID20535
Interacting DomainProtein kinase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9691039
CommentsThe FXFP motif in the Caenorhabditis elegans transcription factor LIN-1 that mediates binding to mouse MAP kinase 1 (or ERK-2)

Record No : 16

Instance ID10536
Regular ExpressionFxFP
Motif InstanceFPFP
Bait Uniprot AccessionQ9R1Z8
Bait Uniprot IdentifierVINEX_MOUSE
Bait Gene NameSorbs3
Bait OrganismMus musculus (Mouse)
Sequence Position630-633
Critical ResiduesP1; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20536
Interacting DomainProtein kinase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15184391
CommentsThe FXFP motif in mouse Vinexin (Sorbs3) that mediates binding to mouse MAP kinase 1 (or ERK-2)

Record No : 17

Instance ID10537
Regular ExpressionFxFP
Motif InstanceFQFP
Bait Uniprot AccessionG5EFD2
Bait Uniprot IdentifierG5EFD2_CAEEL
Bait Gene Nameksr-1
Bait OrganismCaenorhabditis elegans
Sequence Position309-312
Critical ResiduesP1; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20537
Interacting DomainProtein kinase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9925641, 11371562
CommentsThe FXFP motif in Caenorhabditis elegans protein KSR-1 that mediates binding to mouse MAP kinase 1 (or ERK-2)

Record No : 18

Instance ID10538
Regular ExpressionFxFP
Motif InstanceFQFP
Bait Uniprot AccessionP19419
Bait Uniprot IdentifierELK1_HUMAN
Bait Gene NameELK1
Bait OrganismHomo sapiens (Human)
Sequence Position395-398
Critical ResiduesP1; P3; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20538
Interacting DomainProtein kinase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11371562
CommentsThe FXFP motif in human ETS domain-containing protein ELK1 that mediates binding to mouse MAP kinase 1 (or ERK-2)

Record No : 19

Instance ID10539
Regular ExpressionFxFP
Motif InstanceFNFP
Bait Uniprot AccessionP28562
Bait Uniprot IdentifierDUS1_HUMAN
Bait Gene NameDUSP1
Bait OrganismHomo sapiens (Human)
Sequence Position339-342
Critical ResiduesP1; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down(GST tag)
Interaction ID20539
Interacting DomainProtein kinase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9925641, 16286470
CommentsThe FXFP motif in human Mitogen-activated protein (MAP) kinase phosphatase 1 (MKP-1/CL100/DUSP1) that mediates binding to human MAP kinase 1 (or ERK-2)

Record No : 20

Instance ID10540
Regular ExpressionFxFP
Motif InstanceFQFP
Bait Uniprot AccessionP28324
Bait Uniprot IdentifierELK4_HUMAN
Bait Gene NameELK4
Bait OrganismHomo sapiens (Human)
Sequence Position398-401
Critical ResiduesP1; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20540
Interacting DomainProtein kinase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11029469
CommentsThe FXFP motif in human ETS domain-containing protein ELK4 (or SAP1) that mediates binding to human MAP kinase 1 (or ERK-2)




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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)